{"id":1110,"date":"2019-03-21T12:39:30","date_gmt":"2019-03-21T16:39:30","guid":{"rendered":"https:\/\/www.nikola.jp\/needs\/?post_type=job_listing&p=1110"},"modified":"2019-05-31T19:28:27","modified_gmt":"2019-05-31T23:28:27","slug":"1197","status":"publish","type":"job_listing","link":"https:\/\/www.nikola.jp\/needs\/job\/1197\/","title":{"rendered":"1197 \u6d88\u5316\u5668\u7cfb\u75be\u60a3\u306b\u5bfe\u3059\u308b\u5275\u85ac\u5019\u88dc\u3001\u5275\u85ac\u6a19\u7684\u306e\u52df\u96c6"},"content":{"rendered":"

\u52df\u96c6\u8981\u4ef6\u6982\u8981\uff1a\u3000\u5275\u85ac\u5019\u88dc\u304a\u3088\u3073\u5275\u85ac\u6a19\u7684\u5019\u88dc\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/p>\n

\n

\uff25\uff21\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u75be\u60a3A\uff5eF\u306b\u5bfe\u3059\u308b\u5275\u85ac\u5019\u88dc\u3001\u5275\u85ac\u6a19\u7684\u3001\u53ca\u3073\u3053\u306e\u5206\u91ce\u3067\u306e\u5275\u85ac\u7814\u7a76\u30d1\u30fc\u30c8\u30ca\u30fc\u3092\u52df\u96c6\u3057\u3066\u3044\u307e\u3059\u3002\u306a\u304a\u3001\u5275\u85ac\u5019\u88dc\u306e\u30e2\u30c0\u30ea\u30c6\u30a3\u306f\u554f\u3044\u307e\u305b\u3093\uff08\u4f8b\uff1a\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3001\u5929\u7136\u7269\u3001\u30da\u30d7\u30c1\u30c9\u3001\u6297\u4f53\u3001\u6838\u9178\u3001\u7d30\u80de\u6cbb\u7642\uff09\u3002<\/p>\n

\n

A.\u3000\u708e\u75c7\u6027\u8178\u75be\u60a3\uff1aInflammatory bowel disease (IBD)<\/strong>
\n\uff08\u30a2\uff09 \u65e2\u5b58\u306e\u6297\u708e\u75c7\u85ac\u3068\u306f\u7570\u306a\u308b\u6a5f\u5e8f\u306b\u3088\u308a\u3001\u6297\u539f\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u3092\u88dc\u6b63\u3059\u308b\u4e0b\u8a18\u306b\u8a18\u8f09\u306e\u56e0\u5b50\u306b\u95a2\u9023\u3059\u308b\u5275\u85ac\u5019\u88dc\u3082\u3057\u304f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001IBD\u304c\u3042\u308b\u7a2e\u306e\u8178\u5185\u56e0\u5b50\u3078\u306e\u904e\u5ea6\u306e\u514d\u75ab\u5fdc\u7b54\u307e\u305f\u306f\u514d\u75ab\u4e0d\u5168\u3092\u7279\u5fb4\u3068\u3059\u308b\u30d8\u30c6\u30ed\u306a\u75be\u60a3\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u2460 \u81ea\u7136\u514d\u75ab\u7d30\u80de\u306e\u6297\u539f\u8a8d\u8b58\u306e\u8ce6\u6d3b\u5316\uff08TLR\u30a2\u30b4\u30cb\u30b9\u30c8\u3092\u9664\u304f\uff09
\n\u2461 \u904e\u5ea6\u306e\u514d\u75ab\u53cd\u5fdc\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5bdb\u5bb9\u306e\u8a98\u5c0e\u30fb\u518d\u69cb\u7bc9
\n\u2462 \u514d\u75ab\u8a18\u61b6\u306e\u5b8c\u5168\u9664\u53bb\u30fb\u518d\u69cb\u7bc9
\n\u2463 \u708e\u75c7\u53cd\u5fdc\u306e\u7d42\u672b\u5316
\n\uff08\u30a4\uff09 \u30d2\u30c8\u5c0f\u8178\u306b\u304a\u3051\u308b\u7c98\u819c\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u8abf\u7bc0\u306b\u6709\u76ca\u306a\u52b9\u679c\u3092\u6709\u3059\u308b\u4e0b\u8a18\u306b\u8a18\u8f09\u306e\u56e0\u5b50\u306b\u95a2\u9023\u3059\u308b\u5275\u85ac\u5019\u88dc\u3082\u3057\u304f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3002IBD\u306f\u3001\u7c98\u6db2\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304a\u3088\u3073\u8178\u5185\u7d30\u83cc\u7a2e\u306e\u5909\u5316\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002 \u5909\u5316\u3057\u305f\u5fae\u751f\u7269\u306f\u3001\u7c98\u6db2\u5c64\u3092\u52a3\u5316\u3055\u305b\u308b\u304b\u3001\u307e\u305f\u306f\u30e0\u30c1\u30f3\u7523\u751f\u3092\u963b\u5bb3\u3057\u3001\u4e0a\u76ae\u5275\u50b7\u4fee\u5fa9\u3092\u9045\u5ef6\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001IBD\u306e\u75c5\u56e0\u304a\u3088\u3073\/\u307e\u305f\u306f\u91cd\u75c7\u5ea6\u306b\u95a2\u4e0e\u3059\u308b\u3068\u60f3\u5b9a\u3055\u308c\u308b\u3002<\/p>\n

\u2460 \u30d2\u30c8\u5c0f\u8178\u306b\u304a\u3051\u308b\u7c98\u6db2\u5206\u89e3\u30fb\u6d78\u98df\u306e\u6291\u5236\u3000\uff08\u611f\u67d3\u75c7\u4ee5\u5916\uff09
\n\u2461 \u30d2\u30c8\u5c0f\u8178\u306b\u304a\u3051\u308b\u4e0a\u76ae\u7d30\u80de\u5275\u50b7\u6cbb\u7652\u306e\u4fc3\u9032\u3000\uff08\u6210\u9577\u30db\u30eb\u30e2\u30f3\u4ee5\u5916\uff09<\/p>\n

\n

B.\u3000\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u708e\uff1aNon-alcoholic steatohepatitis (NASH)<\/strong>
\n\uff08\u30a2\uff09 FXR agonist\u3042\u308b\u3044\u306fPPAR agonist\u3068\u306f\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u809d\u81d3\u306e\u30d0\u30eb\u30fc\u30cb\u30f3\u30b0\u3001\u708e\u75c7\u3001\u7279\u306b\u7dda\u7dad\u5316\u306b\u5bfe\u3057\u6291\u5236\u4f5c\u7528\u3092\u6709\u3057\u3001\u9ad8\u3044\u5b89\u5168\u6027\u304c\u671f\u5f85\u3055\u308c\u308b\u5275\u85ac\u5019\u88dc\u3002
\n\uff08\u30a4\uff09 NASH\u306e\u81e8\u5e8a\u75c5\u614b\u89e3\u6790\u304b\u3089\u7279\u5b9a\u306e\u60a3\u8005\u96c6\u56e3\u306b\u5bfe\u3057\u3066\u7279\u7570\u7684\u306b\u52b9\u679c\u3092\u793a\u3059\u5275\u85ac\u5019\u88dc\u3002
\n\u5275\u85ac\u5019\u88dc\u306f\u3001\u9ad8\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001NASH\u75c5\u614b\u30e2\u30c7\u30eb\u3067\u306ein vivo\u85ac\u52b9\u30c7\u30fc\u30bf\u3092\u53d6\u5f97\u3057\u3066\u3044\u308b\u3068\u671b\u307e\u3057\u3044\uff08\u98df\u54c1\u6210\u5206\u306f\u9664\u304f\uff09\u3002\u307e\u305f\u3001\u5275\u85ac\u6a19\u7684\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3084\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306a\u3069\u3092\u6709\u3057\u3066\u3044\u308b\u3068\u671b\u307e\u3057\u3044\u3002<\/p>\n

\n

C.\u3000\u904e\u654f\u6027\u8178\u75c7\u5019\u7fa4\uff1aIrritable bowel syndrome (IBS)<\/strong>
\n\uff08\u30a2\uff09 IBS\u306b\u304a\u3051\u308bCNS\u306e\u7570\u5e38\uff08\u4f8b\uff1a\u4e2d\u67a2\u6027\u306e\u75db\u899a\u904e\u654f\u3000\u306a\u3069\uff09\u3092\u6a19\u7684\u3068\u3057\u3066\u3001\u4e0b\u75e2\u3084\u4fbf\u79d8\u306e\u526f\u4f5c\u7528\u7121\u304fIBS\u306e\u8179\u75db\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u308b\u5275\u85ac\u5019\u88dc\u3082\u3057\u304f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3002
\n\u8179\u75db\u6539\u5584\u306b\u52a0\u3048\u3066\u3001\u4e0b\u75e2\u3082\u3057\u304f\u306f\u4fbf\u79d8\u4e00\u65b9\u3060\u3051\u3067\u3082\u6d88\u5316\u7ba1\u904b\u52d5\u7570\u5e38\u3092\u6539\u5584\u3057\u5f97\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3001\u307e\u305f\u306f\u60f3\u5b9a\u3055\u308c\u308b\u5834\u5408\u306f\u3088\u308a\u671b\u307e\u3057\u3044\u3002\u307e\u305f\u3001CNS\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u672b\u68a2\u7d44\u7e54\u3001\u672b\u68a2\u795e\u7d4c\u3092\u4e00\u6b21\u6a19\u7684\u3068\u3057\u3066\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066CNS\u306e\u7570\u5e38\u3092\u6539\u5584\u3057\u5f97\u308b\u5275\u85ac\u5019\u88dc\u3082\u3057\u304f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3067\u3042\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3002
\n\u306a\u304a\u3001\u4e0a\u8a18\u5275\u85ac\u6a19\u7684\u5019\u88dc\u306b\u95a2\u3057\u3066\u306f\u76f4\u63a5\u7684\u307e\u305f\u306f\u9593\u63a5\u7684\u306b\u81e8\u5e8a\u75c5\u614b\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u308b\u5206\u5b50\u6a19\u7684\u3092\u512a\u5148\u3057\u3001probiotics, prebiotics, synbiotics\u304a\u3088\u3073\u98df\u54c1\u6210\u5206\u306f\u9664\u304f\u3002<\/p>\n

\n

D.\u3000NSAID\u8d77\u56e0\u6027\u5c0f\u8178\u7c98\u819c\u50b7\u5bb3\uff1aNSAIDs-induced mucosal injury in small intestine<\/strong>
\n\uff08\u30a2\uff09 NSAIDs\u3084\u4f4e\u7528\u91cf\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u6162\u6027\u670d\u7528\u6642\u306b\u767a\u751f\u3059\u308b\u5c0f\u8178\u7c98\u819c\u50b7\u5bb3\u306b\u5bfe\u3057\u3066\u3001\u4f8b\u3048\u3070\u7c98\u819c\u4e0a\u76ae\u30d0\u30ea\u30a2\u3001\u7c98\u819c\u8840\u6d41\u3001\u8178\u5185\u7d30\u83cc\u306a\u3069\u3078\u306e\u4f5c\u7528\u3092\u4ecb\u3057\u3066\u3001\u4e88\u9632\u52b9\u679c\u3042\u308b\u3044\u306f\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u5275\u85ac\u5019\u88dc\u3082\u3057\u304f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3002
\n\u5275\u85ac\u5019\u88dc\u306f\u6a19\u7684\u5206\u5b50\u304c\u660e\u78ba\u3067\u3042\u308b\u3053\u3068\u3001\u5275\u85ac\u6a19\u7684\u5019\u88dc\u306f\u514d\u75ab\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u3084\u4e0b\u75e2\u7b49\u306e\u526f\u4f5c\u7528\u304c\u306a\u304f\u3001\u5b89\u5168\u6027\u304c\u671f\u5f85\u3067\u304d\u308b\u3082\u306e\u304c\u671b\u307e\u3057\u3044\u3002
\n\u306a\u304a\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u306e\u88dc\u5145\uff08PGE\u8a98\u5c0e\u4f53\u306a\u3069\uff09\u3084\u6297\u751f\u7269\u8cea\u3001NSAIDs\u306e\u6539\u826f\uff08\u88fd\u5264\u5de5\u592b\u3084\u7c98\u819c\u50b7\u5bb3\u3092\u767a\u751f\u3057\u306a\u3044\u65b0\u898f\u6d88\u708e\u93ae\u75db\u5264\u306e\u6a19\u7684\u306a\u3069\uff09\u306a\u3089\u3073\u306bprobiotics, prebiotics, synbiotics\u304a\u3088\u3073\u98df\u54c1\u6210\u5206\u306f\u9664\u304f\u3002<\/p>\n

\n

E.\u3000\u4ed6\u75be\u60a3\u306e\u6cbb\u7642\u306b\u3088\u308b\u6d88\u5316\u7ba1\u526f\u4f5c\u7528<\/strong>
\n\uff08\u30a2\uff09 \u304c\u3093\u3092\u542b\u3080\u69d8\u3005\u306a\u75be\u60a3\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u6d88\u5316\u5668\u306b\u751f\u3058\u308b\u526f\u4f5c\u7528\uff08\u6297\u304c\u3093\u5264\u306b\u3088\u308b\u7c98\u819c\u50b7\u5bb3\u3000\u7b49\uff09\u306b\u5bfe\u3059\u308b\u4e88\u9632\u307e\u305f\u306f\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u5275\u85ac\u5019\u88dc\u3002
\n\u306a\u304a\u4e0a\u8a18\u306e\u5275\u85ac\u5019\u88dc\u306fGLP\u8a66\u9a13\u958b\u59cb\u4ee5\u964d\u3001\u304b\u3064\u81e8\u5e8aPoC\u53d6\u5f97\u524d\u306e\u6bb5\u968e\u306b\u3042\u308b\u3082\u306e\u3068\u3059\u308b\u3002<\/p>\n

\n

F.\u3000\u305d\u306e\u4ed6\u75be\u60a3<\/strong>
\n\uff08\u30a2\uff09 \u304c\u3093\u3092\u9664\u304f\u3001\u6cbb\u7642\u6e80\u8db3\u5ea6\u304c\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u6d88\u5316\u5668\u7cfb\u75be\u60a3\uff08\u4f8b\u3048\u3070\u6162\u6027\u81b5\u708e\u3084\u3001\u6d88\u5316\u5668\u5e0c\u5c11\u75be\u60a3\u3000\u7b49\uff09\u306b\u5bfe\u3057\u3066\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u5275\u85ac\u5019\u88dc\u307e\u305f\u306f\u5275\u85ac\u6a19\u7684\u5019\u88dc\u3002<\/p>\n

——————————————————–<\/p>\n

keywords1: Non-alcoholic steatohepatitis (NASH),Irritable bowel syndrome (IBS),small intestine,adverse reaction,side\u3000effect,gastrointestinal tract,digestive
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\nlanguage :
\ninfocode : m07y12cB31r01
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